Transfer Learning Approach For Multi-Modal Liver Cancer Classification

Authors

  • Sisay Getu Zeleke
  • Ayalew Belay

Keywords:

Classification, Liver cancer, Liver lesion, Multi-modal, Transfer learning

Abstract

Liver cancer is a leading cause of cancer-related deaths worldwide. This study proposes a multi-modal transfer learning approach to classify liver conditions from CT,a MRI, and ultrasound images into normal, benign, and malignant categories. Pre-trained models (VGG16, VGG19, ResNet50, InceptionV3) were fine-tuned using a dataset of 4,050 images from Tikur Anbessa Referral Hospital, preprocessed via resizing and rescaling. Performance was evaluated using accuracy, precision, recall, and F1-score. VGG19 achieved the best results with 90% accuracy and 97% malignant tumor detection, demonstrating its superiority over other models and its suitability for clinical decision-making. The results highlight the advantages of multi-modal imaging over single-modality approaches in reducing diagnostic errors. This transfer learning model effectively leverages pre-trained features to overcome data limitations and aids radiologists by providing rapid, consistent analysis for improved patient outcomes.

References

K. Alawneh , H. Alquran, M. Alsalatie, “LiverNet: Diagnosis of Liver Tumors in Human CT Images,” Applied Sciences, vol. 12, no. 11, p. 5501, May 2022, doi: https://doi.org/10.3390/app12115501

C. Chen, C. Chen, M. Ma, “Classification of multi-differentiated liver cancer pathological images based on deep learning attention mechanism,” BMC Medical Informatics and Decision Making, vol. 22, no. 1, Jul. 2022, doi: https://doi.org/10.1186/s12911-022-01919-1

S. Survarachakan, R. Prasad, R. Naseem, “Deep learning for image-based liver analysis — A comprehensive review focusing on malignant lesions,” Artificial Intelligence in Medicine, vol. 130, pp. 102331–102331, Aug. 2022, doi: https://doi.org/10.1016/j.artmed.2022.102331

Y. A. Ayalew, K. A. Fante, and M. Aliy, “Deep Learning Based Liver Cancer Segmentation from Computed Tomography Images,” Research Square, Aug. 2020, doi: https://doi.org/10.21203/rs.3.rs-65573/v1

C. J. Wang, C. A. Hamm, L. J. Savic, “Deep learning for liver tumor diagnosis part II: convolutional neural network interpretation using radiologic imaging features,” European Radiology, vol. 29, no. 7, pp. 3348–3357, May 2019, doi: https://doi.org/10.1007/s00330-019-06214-8

S. T. Krishna and H. Kumar Kalluri, “Deep learning and transfer learning approaches for image classification,” International Journal of Recent Technology and Engineering , vol. 7, no. 5S4, 2019, doi: https://www.ijrte.org/wp-content/uploads/papers/v7i5s4/E10900275S419.pdf

P. Jain and M. Rifai, “Liver Disease Detection from CT scan images using Deep Learning and Transfer Learning MSc Research Project Data Analytics,” National College of Ireland, 2020. Available: https://norma.ncirl.ie/4398/1/parasjain.pdf

R. Godasu, D. Zeng, and K. Sutrave, “Transfer Learning in Medical Image Classification: Challenges and Opportunities,” AIS Electronic Library (AISeL), 2020. https://aisel.aisnet.org/mwais2020/18

B. Schmauch, “Diagnosis of focal liver lesions from ultrasound using deep learning,” Diagnostic and Interventional Imaging, vol. 100, no. 4, pp. 227–233, Apr. 2019, doi: https://doi.org/10.1016/j.diii.2019.02.009

M. Heker and H. Greenspan, “Joint Liver Lesion Segmentation and Classification via Transfer Learning,” arXiv.org, 2020. http://arxiv.org/abs/2004.12352

H. Zhang, M. Cheng, “Multi-Source Transfer Learning Via Multi-Kernel Support Vector Machine Plus for B-Mode Ultrasound-Based Computer-Aided Diagnosis of Liver Cancers,” IEEE Journal of Biomedical and Health Informatics, vol. 25, no. 10, pp. 3874–3885, Oct. 2021, doi: https://doi.org/10.1109/jbhi.2021.3073812

N. Mizouri, “Deep learning neural network with transfer learning for liver cancer classification,” Research Square (Research Square), Dec. 2022, doi: https://doi.org/10.21203/rs.3.rs-2355564/v1

M. K. Elbashir, A. Mahmoud, A. Mohamed Mostafa, “A Transfer Learning Approach Based on Ultrasound Images for Liver Cancer Detection,” Computers, Materials & Continua, vol. 75, no. 3, pp. 5105–5121, 2023, doi: https://doi.org/10.32604/cmc.2023.037728

S. Zhen, M. Cheng, Y. Tao, Y, F, Wang, “Deep Learning for Accurate Diagnosis of Liver Tumor Based on Magnetic Resonance Imaging and Clinical Data,” Frontiers in Oncology, vol. 10, May 2020, doi: https://doi.org/10.3389/fonc.2020.00680

A. N. Lauren, “Predictors of households at risk for food insecurity in the United States during the COVID-19 pandemic,” Public Health Nutrition, vol. 24, no. 12, pp. 1–19, Jan. 2021, doi: https://doi.org/10.1017/s1368980021000355

H. Abdelhamid Kandel, “Deep Learning Techniques for Medical Image Classification. ProQuest. https://www.proquest.com/openview/b45be1e8b2271e19e9c0a0a4b35dd98e/1?pq-origsite=gscholar&cbl=2026366&diss=y

N. Tajbakhsh, “Convolutional Neural Networks for Medical Image Analysis: Full Training or Fine Tuning?” IEEE Transactions on Medical Imaging, vol. 35, no. 5, pp. 1299–1312, May 2016, doi: https://doi.org/10.1109/tmi.2016.2535302

J. Deng, W. Dong, R. Socher, L.-J. Li, K. Li, and L. Fei-Fei, “ImageNet: A large-scale hierarchical image database,” 2009 IEEE Conference on Computer Vision and Pattern Recognition, pp. 248–255, Jun. 2009, doi: https://doi.org/10.1109/cvpr.2009.5206848.

A. Krizhevsky, I. Sutskever, and G. E. Hinton, “ImageNet Classification with Deep Convolutional Neural Networks,” Communications of the ACM, vol. 60, no. 6, pp. 84–90, May 2012, https://proceedings.neurips.cc/paper_files/paper/2012/file/c399862d3b9d6b76c8436e924a68c45b-Paper.pdf

H.-C. Shin, “Deep Convolutional Neural Networks for Computer-Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning,” IEEE Transactions on Medical Imaging, vol. 35, no. 5, pp. 1285–1298, May 2016, doi: https://doi.org/10.1109/tmi.2016.2528162

M. Raghu, C. Zhang, and J. Kleinberg, “Transfusion: understanding transfer learning for medical imaging,” Proceedings of the 33rd International Conference on Neural Information Processing Systems, 2019. https://dl.acm.org/doi/abs/10.5555/3454287.3454588

T. Hattiya, “Diabetic Retinopathy Detection Using Convolutional Neural Network: A Comparative Study on Different Architectures,” Tci-thaijo.org, 2015. https://ph02.tci-thaijo.org/index.php/mijet/index

K. Sahinbas and F. O. Catak, “Transfer learning-based convolutional neural network for COVID-19 detection with X-ray images,” Data Science for COVID-19, pp. 451–466, 2021, doi: https://doi.org/10.1016/b978-0-12-824536-1.00003-4

A. Szegedy, V. Vanhoucke, S. Ioffe, J. Shlens, and Z. Wojna, “Rethinking the Inception Architecture for Computer Vision,” 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), pp. 2818–2826, Jun. 2016, doi: https://doi.org/10.1109/cvpr.2016.308

H. Ahmed, K. Rahouma, and M. Massoud, “Automated Detection of Primary Liver Cancer Using Different Deep Learning Approaches,” Journal of Advanced Engineering Trends, vol. 43, no. 1, pp. 433–449, Jan. 2024, doi: https://doi.org/10.21608/jaet.2024.255537.1269

N. N. Prakash, V. Rajesh, D. L. Namakhwa, S. Dwarkanath Pande, and S. H. Ahammad, “A DenseNet CNN-based liver lesion prediction and classification for future medical diagnosis,” Scientific African, vol. 20, p. e01629, Jul. 2023, doi: https://doi.org/10.1016/j.sciaf.2023.e01629

H. Kim, “Deep Learning,” Springer eBooks, pp. 247–303, Jan. 2022, doi: https://doi.org/10.1007/978-3-030-95041-5_6

A. Krishan and D. Mittal, “Ensembled liver cancer detection and classification using CT images,” Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, vol. 235, no. 2, pp. 232–244, Nov. 2020, doi: https://doi.org/10.1177/0954411920971888

G. H. L, F. Flammini, S. Srividhya, C. M. L, and S. Selvam, Computer Science Engineering. Informa, 2024. doi: https://doi.org/10.1201/9781003565024

A. Kanan, B. Pereira, C. Hordonneau, “Deep learning CT reconstruction improves liver metastases detection,” Insights into Imaging, vol. 15, no. 1, Jul. 2024, doi: https://doi.org/10.1186/s13244-024-01753-1

A. I. Choi, J. M. Lee, T. K. Kim, M. D. Burgio, and V. Vilgrain, “Diagnosing Borderline Hepatic Nodules in Hepatocarcinogenesis: Imaging Performance,” American Journal of Roentgenology, vol. 205, no. 1, pp. 10–21, Jul. 2015, doi: https://doi.org/10.2214/ajr.14.12655

A. Messina, “Diffusion-Weighted Imaging in Oncology: An Update,” Cancers, vol. 12, no. 6, p. 1493, Jun. 2020, doi: https://doi.org/10.3390/cancers12061493

A. M. Gerges, M. A. Abo, M. M. Fawzi, A. H. Hassan, A. S. Badr, and S. S. Madkour, “Role of Doppler Ultrasound and Triphasic CT in differentiation between benign and malignant portal vein thrombosis.” Journal of Medicine in Scientific Research, vol. 7, no. 3, Jan. 2024, doi: https://doi.org/10.59299/2537-0928.1078

A. Oh, L. Bhardwaj, G. Cacciamani, M. M. Desai, and V. A. Duddalwar, “Cost-effectiveness of Contrast-Enhanced Ultrasound for Diagnosis and Active Surveillance of Complex Cystic Renal Lesions,” Urology Practice, vol. 10, no. 1, Oct. 2022, doi: https://doi.org/10.1097/upj.0000000000000354

Y. Bi, B. Xue, and M. Zhang, Genetic Programming for Image Classification. Springer Nature, 2021. doi: https://doi.org/10.1007/978-3-030-65927-1

J. Xie, “Transfer Learning with Deep Neural Networks for Computer Vision,” Washington.edu, May 02, 2019. https://digital.lib.washington.edu/researchworks/items/d3a595fe-c6c8-4a77-9a14-5028ba563eae/full.

A. S. Paymode, S. P. Magar, and V. B. Malode, “Tomato Leaf Disease Detection and Classification using Convolution Neural Network,” 2021 International Conference on Emerging Smart Computing and Informatics (ESCI), Mar. 2021, doi: https://doi.org/10.1109/esci50559.2021.9397001

A. N. Lauren, “Predictors of households at risk for food insecurity in the United States during the COVID-19 pandemic,” Public Health Nutrition, vol. 24, no. 12, pp. 1–19, Jan. 2021, doi: https://doi.org/10.1017/s1368980021000355

G. Simon and C. Aliferis, “From ‘Human versus Machine’ to ‘Human with Machine,’” Health Informatics, pp. 525–542, 2024, doi: https://doi.org/10.1007/978-3-031-39355-6_11

J. Deng, W. Dong, R. Socher, L.-J. Li, K. Li, and L. Fei-Fei, “ImageNet: A large-scale hierarchical image database,” 2009 IEEE Conference on Computer Vision and Pattern Recognition, pp. 248–255, Jun. 2009, doi: https://doi.org/10.1109/cvpr.2009.5206848

G. Litjens, T. Kooi, B. E. Bejnordi, “A Survey on Deep Learning in Medical Image Analysis,” Medical Image Analysis, vol. 42, no. 1, pp. 60–88, Dec. 2017, doi: https://doi.org/10.1016/j.media.2017.07.005

K. Simonyan and A. Zisserman, “Very deep convolutional networks for large-scale image recognition,” 3rd Int. Conf. Learn. Represent. ICLR 2015 - Conf. Track Proc., pp. 1–14, 2015. https://doi.org/10.48550/arXiv.1409.1556

A. Brodzicki, M. Piekarski, D. Kucharski, J. Jaworek-Korjakowska, and M. Gorgon, “Transfer Learning Methods as a New Approach in Computer Vision Tasks with Small Datasets,” Foundations of Computing and Decision Sciences, vol. 45, no. 3, pp. 179–193, Sep. 2020, doi: https://doi.org/10.2478/fcds-2020-0010

A. M. Anderson, E. Y. Lin, C. Y. Cardenas, D. Gress, “Automated Contouring of Contrast and Noncontrast Computed Tomography Liver Images With Fully Convolutional Networks,” Advances in Radiation Oncology, May 2020, doi: https://doi.org/10.1016/j.adro.2020.04.023

Published

2025-09-22

How to Cite

Sisay Getu Zeleke, & Ayalew Belay. (2025). Transfer Learning Approach For Multi-Modal Liver Cancer Classification. International Journal of Data Science, Bioinformatics and Cyber Security, 1(2), 17–36. Retrieved from https://www.matjournals.net/engineering/index.php/IJDSBCS/article/view/2462